lmoreno
Enhancing the protection of biologically active magnesium with smart coatings for bone repair implants
Marjorie Olivier
Material Science Department
2024-04-15
2026-04-14
Temporary orthopedic implants for bone fractures must be removed by a second surgical intervention after the healing process. This leads an economic cost of 57(B)€ for hospitals and the biomedical industry in Europe, and the risks associated with the interventions. Another major problem associated with these double intervention surgeries is the risk of infection. Bacterial infections are one of the greatest challenges humanity currently confronts. This project focuses on the development of smart multilayer systems capable of degrading in the body. The multilayer system consisting of a ceramic and a porous sol-gel coatingwill be developed, where this will be functionalized with antibiotics or anti-inflammatory agents on biodegradable Mg alloy minimizing the risk of rejection by controlled release. The degradation of the system and the release of the drug will be monitored to evaluate its corrosion behavior. For next step will be the design a 3D prototype to validate in in vitro test.
1. M. Muñoz, J. P. Fernández, B. Torres, N. Pulido, G. Zhang, V. Shanov, L. Moreno, E. Matykina, J. Rams. Plasma electrolytic oxidation of AZ31 magnesium stents for degradation rate control. Surface and Coatings Technology, 2024, 130539.
2. L. Moreno*, M. Mohedano, R. Arrabal, E. Matykina. Screening of fluoride-free PEO coatings on cast Mg3Zn0.4Ca alloy for orthopaedic implants. Surface and Coatings Technology, 2024, 476, 0257-8972.
3. A. Nicolao-Gómez, E. Martínez-Campos, L. Moreno, J. Rodríguez-Hernández, E. Matykina. Hierarchical Hybrid Coatings with Drug-Eluting Capacity for Mg Alloy. Biomaterials. Materials, 2023,16(24), 7688.
4. L. Moreno*, Marta Mohedano, Raúl Arrabal, Juan Rodríguez-Hernández, Endzhe Matykina. Development of hybrid hierarchical coatings on Mg3Zn0.4Ca alloy for orthopaedic implants. Journal of Materials Research and Technology, 2023, 24, 5823-5838.
5. L. Moreno, A. K. Yasakau, C. Blawert, R. Arrabal, E. Matykina and M. Mohedano*. As-cast and extruded Mg-Zn-Ca systems for biodegradable implants: characterization and corrosion behaviour. Journal of Magnesium and Alloys, 2023.
6. L. Moreno*, C. Wang, S. Lamaka, M. L. Zheludkevich, J. Rodríguez-Hernández R. Arrabal and E. Matykina. Ciprofloxacin release and corrosion behaviour of a hybrid PEO/PCL coating on Mg3Zn0.4Ca alloy. Journal of Functional biomaterials, 2023, 14(2), 65.
7. L. Moreno*, M. Mohedano, B. Mingo, R. Arrabal and E. Matykina. Development and screening of (Ca-P-Si-F)-PEO coatings for biodegradability control of Mg-Zn-Ca alloys. Journal of Magnesium and Alloys, 2022, 10 (8), 2220-2237.
8. A. Santos-Coquillat*, E. Martínez-Campos, H. Mora Sánchez, L. Moreno, R. Arrabal, M. Mohedano, A. Gallardo, J. Rodríguez-Hernández and E. Matykina. Hybrid functionalized coatings on Metallic Biomaterials for Tissue Engineering. Surface and Coatings Technology, 2021, 422, 127508.
9. E. Wierzbicka*, B. Vaghefinazari, S. V. Lamaka, M. L. Zheludkevich, M. Mohedano, L. Moreno, P. Visser, A. Rodriguez, J. Velasco, R. Arrabal, E. Matykina. Flash-PEO as an alternative to chromate conversion coatings for corrosion protection of Mg alloy. Corrosion Science, 2021, 180, 109189.
10. L. Moreno*, M. Mohedano, B. Mingo, R. Arrabal and E. Matykina. Degradation behaviour of Mg0.6Ca and Mg0.6Ca2Ag alloys with bioactive plasma electrolytic oxidation coatings. Coatings, 2019, 9 (6), 383
| Name | Lara Moreno |
| Birthdate | 28 years old |
| Country | |
| Contact email | |
